Sarah Dierking of Children's Mercy Hospital in Kansas City, Missouri asked " What is the recommended frequency for cleaning the RxCrush Pill Crusher?" This depends on your protocol for crushing meds in your hospital. We recommend after each hazardous drug preparation the pill crusher ought to be cleaned. When using non-hazardous drugs the pill crusher can be cleaned as needed depending on spillage of medication. When RxCrush pill crushing pouches are used, contamination is unlikely making cleaning less necessary after each use.